Insulin Induces Internalization of the Plasma Membrane 5-Hydroxytryptamine2A (5-HT2A) Receptor in the Isolated Human Endothelium-Denuded Saphenous Vein via the Phosphatidylinositol 3-Kinase Pathway

• Main Authors: Tasuku Kanai (Author), Masachika Kuwabara (Author), Naoko Tanaka-Totoribe (Author), Eisaku Nakamura (Author), Yasuko Matsuo (Author), Shuji Gamoh (Author), Akito Suzuki (Author), Yujiro Asada (Author), Hiroaki Hisa (Author), Ryuichi Yamamoto (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to investigate the relaxant effect of insulin on the 5-hydroxytryptamine (5-HT)-induced constriction of the human endothelium-denuded saphenous vein (SV) and its signal transduction pathway. During the 5-HT-induced sustained constriction of vessels, insulin induced vasorela...