Safety, tolerability, and biomarkers of the treatment of mice with aerosolized toll-like receptor ligands

• Main Authors: Victoria eAlfaro (Author), David L. Goldblatt (Author), Gabriella R. Valverde (Author), Mark eMunsell (Author), Lee J. Quinton (Author), Adam K. Walker (Author), Robert eDantzer (Author), Atul eVaradhachary (Author), Brenton L. Scott (Author), Scott E. Evans (Author), Michael J. Tuvim (Author), Burton F Dickey (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have previously discovered a synergistically therapeutic combination of two Toll-like receptor (TLR) ligands, an oligodeoxynucleotide (ODN) and Pam2CSK4. Aerosolization of these ligands stimulates innate immunity within the lungs to prevent pneumonia from bacterial and viral pathogens. Here we ex...