Engineering of near-PAMless adenine base editor with enhanced editing activity and reduced off-target
About 47% of pathogenic point mutations could be corrected by ABE-induced A·T-to-G·C conversions. However, the applications of ABEs are still hindered by undesired editing efficiency, limited editing scopes, and off-targeting effects. Here, we develop a new adenine base editor, by embedding TadA-8e...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Book |
| Published: |
Elsevier,
2022-06-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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