JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression

• Main Authors: Chenxi Shi (Author), Beili Hao (Author), Yang Yang (Author), Ishfaq Muhammad (Author), Yuanyuan Zhang (Author), Yicong Chang (Author), Ying Li (Author), Changwen Li (Author), Rui Li (Author), Fangping Liu (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2019-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Acetaminophen (APAP) is an analgesic-antipyretic drug and widely used in clinics. Its overdose may cause serious liver damage. Here, we examined the mechanistic role of c-Jun N-terminal kinase (JNK) signaling pathway in liver injury induced by different doses of APAP. Male mice were treated with APA...