JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression

JNK Signaling Pathway Mediates Acetaminophen-Induced Hepatotoxicity Accompanied by Changes of Glutathione S-Transferase A1 Content and Expression

Acetaminophen (APAP) is an analgesic-antipyretic drug and widely used in clinics. Its overdose may cause serious liver damage. Here, we examined the mechanistic role of c-Jun N-terminal kinase (JNK) signaling pathway in liver injury induced by different doses of APAP. Male mice were treated with APA...

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Main Authors: Chenxi Shi (Author), Beili Hao (Author), Yang Yang (Author), Ishfaq Muhammad (Author), Yuanyuan Zhang (Author), Yicong Chang (Author), Ying Li (Author), Changwen Li (Author), Rui Li (Author), Fangping Liu (Author)
Format: Book
Published: Frontiers Media S.A., 2019-09-01T00:00:00Z.
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