Phosphorus containing analogues of SAHA as inhibitors of HDACs

• Main Authors: Michael D. Pun (Author), Hsin-Hua Wu (Author), Feyisola P. Olatunji (Author), Britany N. Kesic (Author), John W. Peters (Author), Clifford E. Berkman (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deacetylases (HDACs) are a family of enzymes responsible for regulating DNA transcription by modulating its binding to histone proteins. HDACs are overexpressed in several types of cancers and are recognised as drug targets. Vorinostat, or suberanilohydroxamic acid (SAHA), is an histone deac...