RERE deficiency leads to decreased expression of GATA4 and the development of ventricular septal defects

• Main Authors: Bum Jun Kim (Author), Hitisha P. Zaveri (Author), Valerie K. Jordan (Author), Andres Hernandez-Garcia (Author), Daron J. Jacob (Author), Diana L. Zamora (Author), Wei Yu (Author), Robert J. Schwartz (Author), Daryl A. Scott (Author)
• Format: Book
• Published: The Company of Biologists, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deletions of chromosome 1p36 are associated with a high incidence of congenital heart defects (CHDs). The arginine-glutamic acid dipeptide repeats gene (RERE) is located in a critical region for CHD on chromosome 1p36 and encodes a cardiac-expressed nuclear receptor co-regulator. Mutations affecting...