A phase I thorough QT/QTc study evaluating therapeutic and supratherapeutic doses of avacopan in healthy participants

• Main Authors: Shichang Miao (Author), Peter Staehr (Author), Ezra Tai (Author), Borje Darpo (Author), Hongqi Xue (Author), Danielle Armas (Author), Kenneth Webster (Author), Rajneet K. Oberoi (Author)
• Format: Book
• Published: Wiley, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract This phase I thorough QTc, double‐blind, randomized, placebo‐ and positive‐controlled, parallel group, multiple‐dose study evaluated avacopan's effect on cardiac repolarization using concentration‐QTc (C‐QTc) as the primary analysis. Avacopan 30 mg b.i.d. (therapeutic dose) was adminis...