Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1

• Main Authors: Yu Jin (Author), Zhen Liu (Author), Zhenxia Li (Author), Hairui Li (Author), Cheng Zhu (Author), Ruomei Li (Author), Ting Zhou (Author), Bing Fang (Author)
• Format: Book
• Published: Nature Publishing Group, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Osteoarthritis (OA) is a prevalent joint disease with no effective treatment strategies. Aberrant mechanical stimuli was demonstrated to be an essential factor for OA pathogenesis. Although multiple studies have detected potential regulatory mechanisms underlying OA and have concentrated on...