Quantitative bias analysis for external control arms using real-world data in clinical trials: a primer for clinical researchers

• Main Authors: Kristian Thorlund (Author), Stephen Duffield (Author), Sanjay Popat (Author), Sreeram Ramagopalan (Author), Alind Gupta (Author), Grace Hsu (Author), Paul Arora (Author), Vivek Subbiah (Author)
• Format: Book
• Published: Becaris Publishing Limited, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of medicines in rare oncologic patient populations are growing, but well-powered randomized controlled trials are typically extremely challenging or unethical to conduct in such settings. External control arms using real-world data are increasingly used to supplement clinical trial evide...