Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1β and Interleukin-18 from Human Monocytes

• Main Authors: Kristine Midtbö (Author), Daniel Eklund (Author), Eva Särndahl (Author), Alexander Persson (Author)
• פורמט: ספר
• יצא לאור: Hindawi Limited, 2020-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Inflammasomes cleave and activate interleukin- (IL-) 1β and IL-18 which have both shared and unique biological functions. IL-1β is an important mediator of the acute phase response to infections and tissue damage, whereas IL-18 takes part in activation and tailoring of the adaptive immune response....