Temperature and pH-Dependent Behaviors of mAb Drugs: A Case Study for Trastuzumab

• Main Authors: Fatma Sert (Author), Defne Hız (Author), Mert Gülmez (Author), Selen Ezgi Cankurtaran (Author), Cemre Irmak Kayalan (Author), Hasan Kurt (Author), Meral Yüce (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The distortions in the high-order structure of therapeutic monoclonal antibodies (mAbs) under different environmental conditions acutely affect mAb stability, resulting in altered safety, efficacy, and shelf-life profiles. The overall stability of mAbs depends on many factors, and it requires comple...