Computational Identification of Novel Kir6 Channel Inhibitors

• Main Authors: Xingyu Chen (Author), Arthur Garon (Author), Marcus Wieder (Author), Marien J. C. Houtman (Author), Eva-Maria Z (Author), Thierry Langer (Author), Marcel A. G. van der Heyden (Author), Anna Stary-Weinzinger (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

KATP channels consist of four Kir6.x pore-forming subunits and four regulatory sulfonylurea receptor (SUR) subunits. These channels couple the metabolic state of the cell to membrane excitability and play a key role in physiological processes such as insulin secretion in the pancreas, protection of...