Spatiotemporal Correlation Spectroscopy Reveals a Protective Effect of Peptide-Based GLP-1 Receptor Agonism against Lipotoxicity on Insulin Granule Dynamics in Primary Human β-Cells

• Main Authors: Gianmarco Ferri (Author), Marta Tesi (Author), Luca Pesce (Author), Marco Bugliani (Author), Francesca Grano (Author), Margherita Occhipinti (Author), Mara Suleiman (Author), Carmela De Luca (Author), Lorella Marselli (Author), Piero Marchetti (Author), Francesco Cardarelli (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glucagon-like peptide-1 receptor (GLP-1R) agonists are being used for the treatment of type 2 diabetes (T2D) and may have beneficial effects on the pancreatic β-cells. Here, we evaluated the effects of GLP-1R agonism on insulin secretory granule (ISG) dynamics in primary β-cells isolated from human...