Inducible overexpression of adiponectin receptors highlight the roles of adiponectin-induced ceramidase signaling in lipid and glucose homeostasis

• Main Authors: William L. Holland (Author), Jonathan Y. Xia (Author), Joshua A. Johnson (Author), Kai Sun (Author), Mackenzie J. Pearson (Author), Ankit X. Sharma (Author), Ezekiel Quittner-Strom (Author), Trevor S. Tippetts (Author), Ruth Gordillo (Author), Philipp E. Scherer (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adiponectin and the signaling induced by its cognate receptors, AdipoR1 and AdipoR2, have garnered attention for their ability to promote insulin sensitivity and oppose steatosis. Activation of these receptors promotes the deacylation of ceramide, a lipid metabolite that appears to play a...