Inhibitory Effect of Cibenzoline on Na+/Ca2+ Exchange Current in Guinea-Pig Cardiac Ventricular Myocytes
The effect of cibenzoline, a class I antiarrhythmic drug, on Na+/Ca2+ exchange current (INCX) was investigated using the patch-clamp method. Cibenzoline inhibited the bi-directional INCX in a concentration-dependent manner. The IC50 values of cibenzoline for the outward and inward components of INCX...
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Main Authors: | Tomomi Yamakawa (Author), Yasuhide Watanabe (Author), Hiroshi Watanabe (Author), Junko Kimura (Author) |
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Format: | Book |
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Elsevier,
2012-01-01T00:00:00Z.
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