Tight junctions in Hailey-Hailey and Darier's diseases

• Main Authors: Laura Raiko (Author), Pekka Leinonen (Author), Päivi Hägg (Author), Juha Peltonen (Author), Aarne Oikarinen (Author), Sirkku Peltonen (Author)
• Format: Book
• Published: PAGEPress Publications, 2009-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hailey-Hailey disease (HHD) and Darier's disease (DD) are caused by mutations in Ca2+-ATPases with the end result of desmosomal disruption and suprabasal acantholysis. Tight junctions (TJ) are located in the granular cell layer in normal skin and contribute to the epidermal barrier. Aberrations...