The impact of CYP2C9 and VKORC1 genetic polymorphisms in anticoagulant therapy management after cardiac surgery with extracorporeal circulation

• Main Authors: Milena Velizarova (Author), Julieta Hristova (Author), Dobrin Svinarov (Author), Stefka Ivanova (Author), Stefanija Jovinska (Author), Philip Abedinov (Author)
• Format: Book
• Published: Pensoft Publishers, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Extracorporeal circulation during cardiac surgery is characterized with increased risk for hypercoagulation because blood is exposed to foreign, nonendothelial cell surfaces. Thus, the usage of extracorporeal circulation is essentially not possible without anticoagulation. Open-heart surgery as well...