Advancing drug innovation for neglected diseases-criteria for lead progression.

• Main Authors: Solomon Nwaka (Author), Bernadette Ramirez (Author), Reto Brun (Author), Louis Maes (Author), Frank Douglas (Author), Robert Ridley (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The current drug R&D pipeline for most neglected diseases remains weak, and unlikely to support registration of novel drug classes that meet desired target product profiles in the short term. This calls for sustained investment as well as greater emphasis in the risky upstream drug discovery. Ac...