Improving Nefiracetam Dissolution and Solubility Behavior Using a Cocrystallization Approach

• Main Authors: Xavier Buol (Author), Koen Robeyns (Author), Camila Caro Garrido (Author), Nikolay Tumanov (Author), Laurent Collard (Author), Johan Wouters (Author), Tom Leyssens (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this work, we are the first to identify thirteen cocrystals of Nefiracetam, a poor water-soluble nootropic compound. Three of which were obtained with the biocompatible cocrystallization agents citric acid, oxalic acid, and zinc chloride. These latter have been fully structurally and physically c...