HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals

• Main Authors: Daniel Bandarra (Author), John Biddlestone (Author), Sharon Mudie (Author), H.-Arno J. Müller (Author), Sonia Rocha (Author)
• Format: Book
• Published: The Company of Biologists, 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia and inflammation are intimately linked. It is known that nuclear factor κB (NF-κB) regulates the hypoxia-inducible factor (HIF) system, but little is known about how HIF regulates NF-κB. Here, we show that HIF-1α represses NF-κB-dependent gene expression. HIF-1α depletion results in increase...