Allelic variation in HLA‐DRB1 is associated with development of antidrug antibodies in cancer patients treated with atezolizumab that are neutralizing in vitro

• Główni autorzy: Christian Hammer (Autor), Jane Ruppel (Autor), Lynn Kamen (Autor), Julie Hunkapiller (Autor), Ira Mellman (Autor), Valerie Quarmby (Autor)
• Format: Książka
• Wydane: Wiley, 2022-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract The treatment of diseases with biologic agents can result in the formation of antidrug antibodies (ADA). Although drivers for ADA formation are unknown, a role for antigen presentation is likely, and variation in human leukocyte antigen (HLA) genes has been shown to be associated with occur...