Monocytes play an IL-12-dependent crucial role in driving cord blood NK cells to produce IFN-g in response to Trypanosoma cruzi.

• Main Authors: Aline Guilmot (Author), Julie Bosse (Author), Yves Carlier (Author), Carine Truyens (Author)
• Format: Bog
• Udgivet: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Fag: article
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We previously reported that foetuses congenitally infected with Trypanosoma cruzi, the agent of Chagas disease, mount an adult-like parasite-specific CD8(+) T-cell response, producing IFN-g, and present an altered NK cell phenotype, possibly reflecting a post-activation state supported by the abilit...