Study on Formulation, in vivo Exposure, and Passive Targeting of Intravenous Itraconazole Nanosuspensions

• Main Authors: Qi Yuan (Author), Yanling Wang (Author), Rufeng Song (Author), Xianqiao Hou (Author), Keke Yu (Author), Jiaojiao Zheng (Author), Juanmei Zhang (Author), Xiaohui Pu (Author), Jihong Han (Author), Lanlan Zong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetic profile of a drug can be different when delivered as a nanosuspension compared with a true solution, which may in turn affect the therapeutic effect of the drug. The goal of this study was to prepare itraconazole nanosuspensions (ITZ-Nanos) stabilized by an amphipathic polymer, p...