Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma

• Main Authors: Muthu K. Shanmugam (Author), Kwang S. Ahn (Author), Jong H. Lee (Author), Radhamani Kannaiyan (Author), Nurulhuda Mustafa (Author), Kanjoormana A. Manu (Author), Kodappully S. Siveen (Author), Gautam Sethi (Author), Wee J. Chng (Author), Alan P. Kumar (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several lines of evidence have demonstrated that deregulated activation of NF-κB plays a pivotal role in the initiation and progression of a variety of cancers including multiple myeloma (MM). Therefore, novel molecules that can effectively suppress deregulated NF-κB upregulation can potentially red...