Long term therapeutic effects of icariin‐loaded PLGA microspheres in an experimental model of optic nerve ischemia via modulation of CEBP‐β/G‐CSF/noncanonical NF‐κB axis

• Main Authors: Tushar Dnyaneshwar Desai (Author), Yao‐Tseng Wen (Author), Jayasimha Rayalu Daddam (Author), Felice Cheng (Author), Chia‐Ching Chen (Author), Chien‐Lin Pan (Author), Keh‐Liang Lin (Author), Rong‐Kung Tsai (Author)
• Format: Book
• Published: Wiley, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract An ischemic insult at optic nerve (ON) is followed by detrimental neuroinflammation that results in progressive and long‐lasting retinal ganglion cell (RGC) death and vision loss. Icariin was reported to be a safe and effective natural anti‐inflammatory drug. Herein, we evaluated the long‐t...