Exorbitant Drug Loading of Metformin and Sitagliptin in Mucoadhesive Buccal Tablet: In Vitro and In Vivo Characterization in Healthy Volunteers

• Main Authors: Rouheena Shakir (Author), Sana Hanif (Author), Ahmad Salawi (Author), Rabia Arshad (Author), Rai Muhammad Sarfraz (Author), Muhammad Irfan (Author), Syed Atif Raza (Author), Kashif Barkat (Author), Fahad Y. Sabei (Author), Yosif Almoshari (Author), Meshal Alshamrani (Author), Muhammad Ali Syed (Author)
• Format: Book
• Published: MDPI AG, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the proposed study is to develop a mucoadhesive buccal delivery system for the sustained delivery of metformin (MET) and sitagliptin (SIT) against diabetes mellitus (DM) with improved bioavailability. Polymeric blend of Carbopol^® 940 (CP), agarose (AG) or polyvinylp...