Mycolactone displays anti-inflammatory effects on the nervous system.

• Main Authors: Caroline Isaac (Author), Annie Mauborgne (Author), Alfonso Grimaldi (Author), Kemy Ade (Author), Michel Pohl (Author), Cristina Limatola (Author), Yves Boucher (Author), Caroline Demangel (Author), Laure Guenin-Macé (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycolactone is a macrolide produced by the skin pathogen Mycobacterium ulcerans, with cytotoxic, analgesic and immunomodulatory properties. The latter were recently shown to result from mycolactone blocking the Sec61-dependent production of pro-inflammatory mediators by immune cells. Here we investi...