Melatonin Targets Metabolism in Head and Neck Cancer Cells by Regulating Mitochondrial Structure and Function

• Main Authors: Ana Guerra-Librero (Author), Beatriz I. Fernandez-Gil (Author), Javier Florido (Author), Laura Martinez-Ruiz (Author), César Rodríguez-Santana (Author), Ying-Qiang Shen (Author), José M. García-Verdugo (Author), Alba López-Rodríguez (Author), Iryna Rusanova (Author), Alfredo Quiñones-Hinojosa (Author), Darío Acuña-Castroviejo (Author), Jordi Marruecos (Author), Tomás De Haro (Author), Germaine Escames (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metabolic reprogramming, which is characteristic of cancer cells that rapidly adapt to the hypoxic microenvironment and is crucial for tumor growth and metastasis, is recognized as one of the major mechanisms underlying therapeutic resistance. Mitochondria, which are directly involved in metabolic r...