Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

• Main Authors: Rafael Mayoral (Author), Olivia Osborn (Author), Joanne McNelis (Author), Andrew M. Johnson (Author), Da Young Oh (Author), Cristina Llorente Izquierdo (Author), Heekyung Chung (Author), Pingping Li (Author), Paqui G. Traves (Author), Gautam Bandyopadhyay (Author), Ariane R. Pessentheiner (Author), Jachelle M. Ofrecio (Author), Joshua R. Cook (Author), Li Qiang (Author), Domenico Accili (Author), Jerrold M. Olefsky (Author)
• Format: Book
• Published: Elsevier, 2015-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-rec...