Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride

• Main Authors: Kaichiro Kamiya (Author), Ryoko Niwa (Author), Mikio Morishima (Author), Haruo Honjo (Author), Michael C. Sanguinetti (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Block of cardiac hERG K+ channels by the antihistamine terfenadine and the prokinetic agent cisapride is associated with prolonged ventricular repolarization and an increased risk of ventricular arrhythmia. Here, we used a site-directed mutagenesis approach to determine the molecular determinants of...