2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).

• Main Authors: Leopoldo Raul Beltran (Author), Madeline eBeltran (Author), Ainhara eAguado (Author), Guenter eGisselmann (Author), Hanns eHatt (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract: Two-pore domain K+ (KCNK, K2P) channels underlie the leak (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability. These channels have been reported to be modulated by several physical and chemical stimuli. The compound...