5-Azacytidine Promotes an Inhibitory T-Cell Phenotype and Impairs Immune Mediated Antileukemic Activity

• Main Authors: Thomas Stübig (Author), Anita Badbaran (Author), Tim Luetkens (Author), York Hildebrandt (Author), Djordje Atanackovic (Author), Thomas M. C. Binder (Author), Boris Fehse (Author), Nicolaus Kröger (Author)
• Format: Book
• Published: Hindawi Limited, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Demethylating agent, 5-Azacytidine (5-Aza), has been shown to be active in treatment of myeloid malignancies. 5-Aza enhances anticancer immunity, by increasing expression of tumor-associated antigens. However, the impact of 5-Aza immune responses remains poorly understood. Here, T-cell mediated tumo...