Determining the contributions of protein synthesis and breakdown to muscle atrophy requires non‐steady‐state equations

• Main Authors: Kamil A. Kobak (Author), Marcus M. Lawrence (Author), Gavin Pharaoh (Author), Agnieszka K. Borowik (Author), Frederick F. Peelor III (Author), Patrick D. Shipman (Author), Timothy M. Griffin (Author), Holly Van Remmen (Author), Benjamin F. Miller (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Ageing and cachexia cause a loss of muscle mass over time, indicating that protein breakdown exceeds protein synthesis. Deuterium oxide (D2O) is used for studies of protein turnover because of the advantages of long‐term labelling, but these methods introduce considerations that...