A Penicillin Derivative Exerts an Anti-Metastatic Activity in Melanoma Cells Through the Downregulation of Integrin αvβ3 and Wnt/β-Catenin Pathway

• Main Authors: Elizabeth Barrionuevo (Author), Florencia Cayrol (Author), Graciela A. Cremaschi (Author), Patricia G. Cornier (Author), Dora B. Boggián (Author), Carina M. L. Delpiccolo (Author), Ernesto G. Mata (Author), Leonor P. Roguin (Author), Viviana C. Blank (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the anti-metastatic potential of this compound on highly metastatic murine B16-F10...