Familial hemiplegic migraine Ca_V2.1 channel mutation R192Q enhances ATP-gated P2X₃receptor activity of mouse sensory ganglion neurons mediating trigeminal pain

• Main Authors: Nair Asha (Author), Simonetti Manuela (Author), Birsa Nicol (Author), Ferrari Michel D (Author), van den Maagdenberg Arn MJM (Author), Giniatullin Rashid (Author), Nistri Andrea (Author), Fabbretti Elsa (Author)
• Format: Book
• Published: SAGE Publishing, 2010-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The R192Q mutation of the CACNA1A gene, encoding for the α1 subunit of voltage-gated P/Q Ca²⁺channels (Ca_v2.1), is associated with familial hemiplegic migraine-1. We investigated whether...