TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

• Main Authors: Shingo Suzuki (Author), R Geoffrey Sargent (Author), Beate Illek (Author), Horst Fischer (Author), Alaleh Esmaeili-Shandiz (Author), Michael J Yezzi (Author), Albert Lee (Author), Yanu Yang (Author), Soya Kim (Author), Peter Renz (Author), Zhongxia Qi (Author), Jingwei Yu (Author), Marcus O Muench (Author), Ashley I Beyer (Author), Alessander O Guimarães (Author), Lin Ye (Author), Judy Chang (Author), Eli J Fine (Author), Thomas J Cradick (Author), Gang Bao (Author), Meghdad Rahdar (Author), Matthew H Porteus (Author), Tsuyoshi Shuto (Author), Hirofumi Kai (Author), Yuet W Kan (Author), Dieter C Gruenert (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystic fibrosis (CF) is a recessive inherited disease associated with multiorgan damage that compromises epithelial and inflammatory cell function. Induced pluripotent stem cells (iPSCs) have significantly advanced the potential of developing a personalized cell-based therapy for diseases like CF by...