Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

• Autors principals: M. Gordon Joyce (Autor), Amy Bao (Autor), Man Chen (Autor), Ivelin S. Georgiev (Autor), Li Ou (Autor), Tatsiana Bylund (Autor), Aliaksandr Druz (Autor), Wing-Pui Kong (Autor), Dongjun Peng (Autor), Emily J. Rundlet (Autor), Joseph G. Van Galen (Autor), Shuishu Wang (Autor), Yongping Yang (Autor), Baoshan Zhang (Autor), Gwo-Yu Chuang (Autor), Jason S. McLellan (Autor), Barney S. Graham (Autor), John R. Mascola (Autor), Peter D. Kwong (Autor)
• Format: Llibre
• Publicat: Case Western Reserve University, 2019-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Background: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) glycoprotein, stabilized in its prefusion conformation by DS-Cav1 mutations, is a promising RSV-vaccine immunogen, capable of bo...