Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

• Main Authors: M. Gordon Joyce (Author), Amy Bao (Author), Man Chen (Author), Ivelin S. Georgiev (Author), Li Ou (Author), Tatsiana Bylund (Author), Aliaksandr Druz (Author), Wing-Pui Kong (Author), Dongjun Peng (Author), Emily J. Rundlet (Author), Joseph G. Van Galen (Author), Shuishu Wang (Author), Yongping Yang (Author), Baoshan Zhang (Author), Gwo-Yu Chuang (Author), Jason S. McLellan (Author), Barney S. Graham (Author), John R. Mascola (Author), Peter D. Kwong (Author)
• Format: Book
• Published: Case Western Reserve University, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Respiratory syncytial virus (RSV) subtypes, A and B, co-circulate in annual epidemics and alternate in dominance. We have shown that a subtype A RSV fusion (F) glycoprotein, stabilized in its prefusion conformation by DS-Cav1 mutations, is a promising RSV-vaccine immunogen, capable of bo...