Enhancing peptide and PMO delivery to mouse airway epithelia by chemical conjugation with the amphiphilic peptide S10

• Main Authors: Maud Auger (Author), Luis Sorroza-Martinez (Author), Nadine Brahiti (Author), Carole-Ann Huppé (Author), Laurence Faucher-Giguère (Author), Imen Arbi (Author), Maxime Hervault (Author), Xue Cheng (Author), Bruno Gaillet (Author), Frédéric Couture (Author), David Guay (Author), Al-Halifa Soultan (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Delivery of antisense oligonucleotides (ASOs) to airway epithelial cells is arduous due to the physiological barriers that protect the lungs and the endosomal entrapment phenomenon, which prevents ASOs from reaching their intracellular targets. Various delivery strategies involving peptide-, lipid-,...