NaHS or Lovastatin Attenuates Cyclosporine A-Induced Hypertension in Rats by Inhibiting Epithelial Sodium Channels

• Main Authors: Qiu-Shi Wang (Author), Chen Liang (Author), Shuai Jiang (Author), Di Zhu (Author), Yu Sun (Author), Na Niu (Author), Xu Yang (Author), Yan-Chao Yang (Author), Bi-Han Dong (Author), Jie Yao (Author), Chang-Jiang Yu (Author), Jie Lou (Author), Liang-Liang Tang (Author), Ming-Ming Wu (Author), Zhi-Ren Zhang (Author), He-Ping Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of cyclosporine A (CsA) in transplant recipients is limited due to its side effects of causing severe hypertension. We have previously shown that CsA increases the activity of the epithelial sodium channel (ENaC) in cultured distal nephron cells. However, it remains unknown whether ENaC medi...