Dantrolene Prevents the Lymphostasis Caused by Doxorubicin in the Rat Mesenteric Circulation

• Main Authors: Serena Van (Author), Soumiya Pal (Author), Brittney R. Garner (Author), Kate Steed (Author), Vijayalakshmi Sridharan (Author), Shengyu Mu (Author), Nancy J. Rusch (Author), Amanda J. Stolarz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Purpose: Doxorubicin (DOX) is a risk factor for arm lymphedema in breast cancer patients. We reported that DOX opens ryanodine receptors (RYRs) to enact "calcium leak," which disrupts the rhythmic contractions of lymph vessels (LVs) to attenuate lymph flow. Here, we evaluate...