The Correlation Between Busulfan Exposure and Clinical Outcomes in Chinese Pediatric Patients: A Population Pharmacokinetic Study

• Main Authors: Xiaohuan Du (Author), Chenrong Huang (Author), Ling Xue (Author), Zheng Jiao (Author), Min Zhu (Author), Jie Li (Author), Jun Lu (Author), Peifang Xiao (Author), Xuemei Zhou (Author), Chenmei Mao (Author), Zengyan Zhu (Author), Ji Dong (Author), Xiaoxue Liu (Author), Zhiyao Chen (Author), Shichao Zhang (Author), Yiduo Ding (Author), Shaoyan Hu (Author), Liyan Miao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: The aims of the study were to 1) establish a population pharmacokinetic (Pop-PK) model for busulfan in Chinese pediatric patients undergoing hematopoietic stem cell transplantation (HSCT) and then estimate busulfan exposure and 2) explore the association between busulfan exposure and clinical...