Formalin Inactivation of Japanese Encephalitis Virus Vaccine Alters the Antigenicity and Immunogenicity of a Neutralization Epitope in Envelope Protein Domain III.

• Main Authors: Yi-Chin Fan (Author), Hsien-Chung Chiu (Author), Li-Kuang Chen (Author), Gwong-Jen J Chang (Author), Shyan-Song Chiou (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Formalin-inactivated Japanese encephalitis virus (JEV) vaccines are widely available, but the effects of formalin inactivation on the antigenic structure of JEV and the profile of antibodies elicited after vaccination are not well understood. We used a panel of monoclonal antibodies (MAbs) to map th...