Dose-response technique combined with stable isotope tracing for drug metabolite profiling by using high-resolution mass spectrometry

• Autori principali: I-Shou Lin (Autore), Chia-Ying Anderin Chuang (Autore), Chia-Lung Shih (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background: Mass spectrometry metabolomics-based data-processing approaches have been developed for drug metabolite profiling. However, existing approaches cannot be used to comprehensively identify drug metabolites with high efficacy.Methods: Herein, we propose a two-stage data-processing approach...