Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+ Myeloid-Derived Suppressor Cells Require HMGB1

Although tissue-derived high mobility group box 1 (HMGB1) is involved in many aspects of inflammation and tissue injury after trauma, its role in trauma-induced immune suppression remains elusive. Using an established mouse model of peripheral tissue trauma, which includes soft tissue and fracture c...

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Main Authors: Xiangcai Ruan (Author), Sophie S. Darwiche (Author), Changchun Cai (Author), Melanie J. Scott (Author), Hans-Christoph Pape (Author), Timothy R. Billiar (Author)
Format: Book
Published: Hindawi Limited, 2015-01-01T00:00:00Z.
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3rd Floor Main Library

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