New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types

• Main Authors: Silpa Gampala (Author), Hye-ran Moon (Author), Randall Wireman (Author), Jacqueline Peil (Author), Sonia Kiran (Author), Dana K. Mitchell (Author), Kylee Brewster (Author), Henry Mang (Author), Andi Masters (Author), Christine Bach (Author), Whitney Smith-Kinnamen (Author), Emma H. Doud (Author), Ratan Rai (Author), Amber L. Mosley (Author), Sara K. Quinney (Author), D. Wade Clapp (Author), Chafiq Hamdouchi (Author), James Wikel (Author), Chi Zhang (Author), Bumsoo Han (Author), Millie M. Georgiadis (Author), Mark R. Kelley (Author), Melissa L. Fishel (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AP endonuclease-1/Redox factor-1 (APE1/Ref-1 or Ref-1) is a multifunctional protein that is overexpressed in most aggressive cancers and impacts various cancer cell signaling pathways. Ref-1's redox activity plays a significant role in activating transcription factors (TFs) such as NFκB, HIF1α,...