Gestational dexamethasone exposure impacts hippocampal excitatory synaptic transmission and learning and memory function with transgenerational effects

• Main Authors: Mingcui Luo (Author), Yiwen Yi (Author), Songqiang Huang (Author), Shiyun Dai (Author), Lulu Xie (Author), Kexin Liu (Author), Shuai Zhang (Author), Tao Jiang (Author), Tingting Wang (Author), Baozhen Yao (Author), Hui Wang (Author), Dan Xu (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The formation of learning and memory is regulated by synaptic plasticity in hippocampal neurons. Here we explored how gestational exposure to dexamethasone, a synthetic glucocorticoid commonly used in clinical practice, has lasting effects on offspring's learning and memory. Adult offspring rat...