Impact of P‐gp inhibition on systemic exposure of pralsetinib and dosing considerations

• 主要な著者: Julia Suchomel (著者), Priya Agarwal (著者), Doreen Anders (著者), Kevin Hughes (著者), Yang Tang (著者), Rucha Sane (著者), Astrid Scalori (著者), Sunil Sharma (著者), Sravanthi Cheeti (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2024-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract A study to determine the impact of cyclosporine (Neoral), an inhibitor of P‐gp, on the pharmacokinetics of pralsetinib (trade name GAVRETO®) was conducted in 15 healthy adult volunteers. A single 200 mg dose of pralsetinib was administered orally alone and in combination with cyclosporine w...