Impact of P‐gp inhibition on systemic exposure of pralsetinib and dosing considerations

Abstract A study to determine the impact of cyclosporine (Neoral), an inhibitor of P‐gp, on the pharmacokinetics of pralsetinib (trade name GAVRETO®) was conducted in 15 healthy adult volunteers. A single 200 mg dose of pralsetinib was administered orally alone and in combination with cyclosporine w...

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Main Authors: Julia Suchomel (Author), Priya Agarwal (Author), Doreen Anders (Author), Kevin Hughes (Author), Yang Tang (Author), Rucha Sane (Author), Astrid Scalori (Author), Sunil Sharma (Author), Sravanthi Cheeti (Author)
Format: Book
Published: Wiley, 2024-06-01T00:00:00Z.
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