HMG-CoA Reductase Inhibitors Suppress Monosodium Urate-Induced NLRP3 Inflammasome Activation through Peroxisome Proliferator-Activated Receptor-γ Activation in THP-1 Cells

Peroxisome proliferator-activated receptor γ (PPAR-γ) is thought to negatively regulate NLRP3 inflammasome activation. The aim of this study was to identify the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) on monosodium urate (MSU) crystal-induc...

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Príomhchruthaitheoirí: Seong-Kyu Kim (Údar), Jung-Yoon Choe (Údar), Ji-Won Kim (Údar), Ki-Yeun Park (Údar)
Formáid: LEABHAR
Foilsithe / Cruthaithe: MDPI AG, 2023-03-01T00:00:00Z.
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