ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock

• Main Authors: Ying Zhang (Author), Ying Lv (Author), Qingju Zhang (Author), Xingfang Wang (Author), Qi Han (Author), Yan Liang (Author), Simeng He (Author), Qiuhuan Yuan (Author), Jiaqi Zheng (Author), Changchang Xu (Author), Xiangxin Zhang (Author), Zichen Wang (Author), Huaxiang Yu (Author), Li Xue (Author), Jiali Wang (Author), Feng Xu (Author), Jiaojiao Pang (Author), Yuguo Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell survival or death is critical for cardiac function. Myocardial pyroptosis, as a newly recognized programmed cell death, remains poorly understood in sepsis. In this study, we evaluated the effect of aldehyde dehydrogenase (ALDH2) on myocardial pyroptosis and revealed the underlying mechanisms i...